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Antibody Mediated Rejection in Liver Transplantation

 

Click here to register!

A NOTE FROM THE CO-CHAIR

I am excited to share with you our recent paper that came out on ePub just last week. It highlights the importance of Donor Specific Antibodies (DSA) in simultaneous liver kidney transplant patients. I am sure this paper will wet your appetite for more data and hope that you join us to learn more about DSA in liver transplantation at our upcoming meeting on March 22-23, 2013. 

Click Here to view this recent publication, and see further details on the Dallas Antibody Mediated Rejection in Liver Transplantation Conference below.

Sincerely,

Jackie O’Leary, MD MPH
Program Co-Chair - Dallas Antibody Mediated Rejection Conference in Liver Transplantation

 

GOALS & PURPOSE

Antibody mediated rejection is a well known and feared entity in all solid organ transplants – except the liver. Although some previous studies in liver allografts have shown donor specific alloantibodies (DSA) to be detrimental, the literature has been inconsistent. However, mounting evidence has shown the pathologic potential of DSA in liver and SLKT recipients. As a result, we have organized a meeting of the minds to define AMR in liver transplantation and forge a path for future research in this burgeoning area of research.

Toward this goal, we ignite the conference by reviewing the history of AMR in other solid organs, outline the lessons not to be relearned, evaluate the natural history and endpoints for studies, and review novel biomarkers of ACR and AMR. Then we review the current state of the art testing, highlighting both HLA and non-HLA antibody testing nuances. After the stage has been set, an in-depth analysis of the current literature focuses separately on the liver allograft and the important implications for patients in receipt of SLKT.  This is followed by debate about the pathologic diagnostic criteria for AMR and the utility of C4d staining. The last section discusses the history of rejection diagnosis and management and how we need to alter this paradigm to incorporate testing, diagnosis and therapy for liver AMR.

Finally, our esteemed consensus panel will recap the important highlights from this game changing conference!

WHO SHOULD ATTEND

Transplant Surgeons, Transplant Pathologists, Transplant Hepatologists, Transplant Nephrologists, and HLA Laboratory PhDs.

PROGRAM FACULTY

CO-DIRECTORS

Göran Klintmalm, MD, PhD, FACS
Baylor Annette C. and Harold C. Simmons Transplant Institute

Dallas/Fort Worth, TX

Jacqueline G. O’Leary, MD, MPH
Baylor Annette C. and Harold C. Simmons Transplant Institute
Dallas/Fort Worth, TX

SPEAKERS INCLUDE

Sir Roy Calne, MD
Addenbrokke’s Hospital
Cambridge, UK

Robert Colvin, MD
Mass. General Hospital
Boston, MA

Jake Demetris, MD
University of Pittsburgh
Pittsburgh, PA

Sandy Feng, MD, PhD
UCSF
San Francisco, CA

Lawrence S. Friedman, MD
Newton-Wellesley Hospital
Newton, MA

Howard M. Gebel, PhD
Emory University Hospital
Atlanta, GA

Philip Halloran, MD, PhD
University of Alberta
Alberta, Canada

Allan Kirk, MD, PhD
Emory University Hospital
Atlanta, GA

Stuart Knechtle, MD
Emory University Hospital
Atlanta, GA

Sue McDiarmid, MD
UCLA
Los Angeles, CA

Larry Melton, MD, PhD
Baylor University Medical Center
Dallas, TX

Abraham Shaked, MD, PhD
University of Pennsylvania
Philadelphia, PA

Peter Stastny, MD
UT Southwestern Med. Center
Dallas, TX

Paul Terasaki, PhD
UCLA
Los Angeles, CA

Angus Thomson, PhD
University of Pittsburgh
Pittsburgh, PA

Kathryn Tinckam, MD
University of Toronto
Toronto, Canada

Stephen Tomlanovich, MD
UCSF
San Francisco, CA

James Trotter, MD
Baylor University Medical Center
Dallas, TX

Flavio Vincenti, MD
UCSF
San Francisco, CA

Kathryn Wood, PhD
University of Oxford
Oxford, UK

E. Steve Woodle, MD
University of Cincinnati
Cincinnati, OH

Andrea Zachary, PhD
John Hopkins Medical Center
Baltimore, MD

AGENDA

THURSDAY, 3/21/2013

 
5:30-7:00 PM  Welcome Reception
                      Adolphus Hotel • Sam Rayburn Room
                      1321 Commerce Street • Dallas, Texas 75202

 

 

FRIDAY 3/22/2013

 

7:15 AM Registration, Breakfast and Welcome (Exhibits Open)
Century Foyer / Century Ballroom

 

8:00 Antibody Mediated Rejection: The Future of Precision Medicine in Liver Transplantation
Göran Klintmalm, MD, PhD, FACS

 

AMR IN RENAL TRANSPLANT

Chairs: Philip Halloran, MD, PhD • Larry Melton, MD, PhD, FACP

 

8:10 History of AMR in Kidney Transplant: Lessons Not to Re-Learn
Paul Terasaki, PhD

 

8:40 Biomarkers of AMR and ACR
Philip Halloran, MD, PhD

 

9:10 Panel Discussion

 

9:50 Break  (Exhibits Open)

 

CURRENT STATE-OF-THE-ART TESTING

Chairs: Howard M. Gebel, PhD • James Trotter, MD

 

10:10 HLA Antibodies: Problems and Solutions
Howard M. Gebel, PhD

 

10:35 Non-HLA Antibodies
Peter Stastny, MD

 

11:00 Epitopes vs. MFI
Kathryn Tinckam, MD, MMSc     

 

11:25 New Insights into Antibody Mediated Graft Injury After Pediatric Liver Transplantation
Sue McDiarmid, MD

 

11:50 Panel Discussion

 

12:30 PM Lunch (Exhibits Open)
Grand Ballroom B

 

HLA ANTIBODIES IN LIVER TRANSPLANT

Chairs: Allan Kirk, MD, PhD • Sandy Feng, MD, PhD

 

1:30 Lessons from Animal Models in AMR
Stuart Knechtle, MD

 

2:00 Is Crossmatch Relevant in Liver Transplantation?
Angus Thomson, PhD, DSc

 

2:30 DSA and Rejection in OLT
Jacqueline G. O’Leary, MD, MPH

 

3:00 DSA in SLKT
Allan Kirk, MD, PhD

 

3:30 DEBATE: Utility of Special Staining in Liver Transplant Biopsies? C4d and Beyond.
• Yes  - Jake Demetris, MD (20 min)
• No - Robert Colvin, MD (20 min)
• Rebuttal -  Drs. Demetris & Colvin (5 min each)

 

4:20 Panel Discussion

 

5:00 Adjourn

 

5:45 Transportation Departs from Hotel Lobby

 

DINNER AND ENTERTAINMMENT

 

6:30-10 PM Perot Museum of Nature & Science
Woodall Rodgers Freeway & Field Street, Dallas
Attire:  Business Casual

 

SATURDAY, 3/23/2013

 

7:15 AM        Breakfast (Exhibits Open)
Century Foyer

 

THERAPY

Chairs: Göran Klintmalm, MD • E. Steve Woodle, MD
Century Ballroom

 

8:00 History of Treating Rejection in Liver Transplantation
Sir Roy Calne, MD, FRCP, FRCS

 

8:30 Monitoring for DSA: Cutoffs and Triggers for Treatment
Andrea Zachary, PhD

 

8:55 Does Long Term Immunosuppression Matter?
Flavio Vincenti, MD          

 

9:20 IVIG vs. Rituximab vs. Proteosome Inhibitors vs. Pheresis
E. Steve Woodle, MD

 

9:45 Panel Discussion

 

10:30 Break (Exhibits Open)

 

 

WHAT HAVE WE LEARNED AND

WHERE ARE WE GOING?

Chair: Göran Klintmalm, MD, PhD, FACS

 

 

THE CONSENSUS PANEL REPORTS

 

 

10:50 AMR Renal Transplant - What Should We Learn?
Abraham Shaked, MD, PD

 

11:05 State-of-the-Art Testing
Kathryn Wood, PhD

 

11:20 AMR in Liver Transplant 
Lawrence S. Friedman, MD

 

11:35 Therapy
Steve Tomlanovich, MD

 

11:50 Concluding Remarks: Where are We Going?
Göran Klintmalm, MD, PhD, FACS

 

12:00 PM Conference Adjourns

 

 


 

ACCREDITATION

CME CREDIT

A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas, is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The A. Webb Roberts Center for Continuing Medical Education of Baylor Health Care System, Dallas, designates this live activity for a maximum of 11.25 AMA PRA Category 1 Credits(TM). Physicians should claim only the credit commensurate with the extent of their participation in the activity.

TRANSPLANT CREDIT

This activity has been approved for a maximum of 12 Category I Continuing Education Points for Transplant Certification (CEPTCs) through the American Board for Transplant Certification (ABTC).

ABHI CREDIT

This activity has been approved for a maximum of 9.5 Continuing Education Points for American Board of Histocompatibility and Immunogenetics (ABHI) through the American Society for Histocompatibility and Immunogenetics (ASHI).

 

     
     
     

ADDITIONAL INFORMATION

VENUE & ACCOMMODATIONS

Adolphus Hotel
1321 Commerce Street • Dallas, TX 75202
Tel: (214) 742-8200 • Web: www.hoteladolphus.com

ACCOMMODATIONS ARE NOT INCLUDED WITH YOUR REGISTRATION.
The Adolphus Hotel is close to capacity at this time.  Please contact their reservations office to determine availability at 214-742-8200.

If you are unable to secure accommodations at the Adolphus, additional rooms may be available at nearby hotels including:

  • Magnolia Hotel – 1401 Commerce St., Dallas, TX 75202  Ph: (214) 915-6500
  • Crowne Plaza Dallas – 1015 Elm St., Dallas, TX 75020 Ph: (214) 742-5678

REGISTRATION & INFORMATION

Click Here to Register Online

Early registration fee of $435 (prior to 3/16/2013) includes two-day conference, all meals, Thursday reception at the Adolphus, and Friday banquet at the Perot Museum of Nature & Science.  Registration is via online only.